Hand And Nail Cream

Refreshing Hand Cream with Vital ET and Proplipid 141
Source: International Speciality Products, Formula 10890-123-2
IngredientsWeight %
Phase A
Deionized water65.70
Carbomer (Carbopol 980)0.30
Disodium EDTA0.10
Glycerin2.00


Phase B
Petrolatum6.00
Ethylhexyl palmitate (Ceraphyl 368)9.50
Glyceryl dilaurate (Emulsynt GDL)2.00
Isodecyl oleate (Ceraphyl 140A)1.50
Glyceryl stearate, behenyl alcohol, palmitate acid, stearic acid, lecithin, lauryl alcohol, myristyl alcohol, Cetyl alcohol (Propilid 141)4.00


Phase C
Triethanolamine0.40
Deionized water5.00


Phase D
Disodium lauraminodipropionate
Tocopheryl phosphate (Vital ET)3.00
Diazolidinyl urea
Butyl carbamate(Germal Plus)0.50

Hand Lotion Formula and Composition

Conditioning hand and body lotion formula, a non-greasy and has a long-lasting silky after feel.
IngredientsWeight %
Part A
ArlasilkTM Stearamidopropyl PG-dimonium chloride phosphate & cetyl alcohol3
Propylene Glycol2
Germaben II (Propylene Glycol, diazolidinyl urea, methyl paraben, Propyl paraben)0.4
Titanium Dioxide0.4
Triethanolamin0.6
Water84.60


Part B
Cetyl alcohol2
ArlatoneTMMAP 160 (Cetyl phosphate)1
Hexyl laurate4
MonasilTMPCA (PCA Dimethicone)2


Total100

Face Cleansing Formulation and Composition

CleansingFrequent and proper hand cleansing can significantly reduce transmission of disease, care must be taken against overwashing.

Two major groups of microorganisms are found on skin :
  • Resident flora : normally reside there.
  • Transient flora : contaminants that are the primary cause of hospital infections from cross contamination in a hospital environmental.
Plain soap and water can physically remove one level of microbes, and in fact may aid in the dispersal of bacteria on the skin of the hands. In order to kill microorganisms an antiseptic agent is necessary. Such cleaners typically contain alcohol and additional antimicrobial agent.

Exfoliating Cuticle Scrub

Regular use of an exfoliant helps to remove the outer layer of dead skin on the hands, feet, and cuticle. The massaging action upon application of the product stimulates blood flow and assists in the generation of new skin cells. The physical result is that the skin feels softer and appears fresher. Exfoliants need to be pH balanced in the same manner as skin cleaners and soaps.

Cuticle Removers Formula and Composition

Cuticle Removers are used when the cuticle is too large and intruding onto the nail plate. They can be in the form of a fluid, lotion, or cream and are applied to the cuticle area followed by gentle massage to the area. Cuticle Removers generally contain either sodium hydroxide or potassium hydroxide and are extremely alkaline. A pH OF 10 or higher is not unheard of. The cuticle will become soft and washes off with gentle rubbing. The use of surfactants can assist in the penetration of the ingredients and speed up the softening of the cuticle.

Cuticle Conditioners And Moisturizers

These products are helpful to maintain the suppleness of the cuticle. This is important because the cuticle is a barrier against infection. Dried and cracked cuticles not only make the manicure difficult, but also can provide sites for entry of bacteria and fungus. These products typically contain good moisturizers or humectants such as urea, hyaluronic acid and its derivates, phospholipids, sodium PCA, glycerin, and others. The role of surfactants will be to assist penetration into the cuticle and make the cream or lotion more effective for its intended purpose.

Medical Products : Antifungal and Antimicrobial

Surfactant is used as emulsifying, stabilizing, property of permeation enhancement of pharmaceutically active ingredient. This surfactant use in :
  • Corn and callus treatment
  • Ingrown toenail treatments
  • Topical antifungal
  • Topical skin protectants
  • Topical antimicrobials (antibiotic)

Extended Release Formulations of Metformin HCl 500 mg

Introduction :
Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide monohydrochloride) is not chemically or pharmacologically related to sulfonylureas, thiazolidinediones, or (alpha)-glucosidase inhibitors.

It is a white to off-white crystalline compound with a molecular formula of C4H12ClN5 (monohydrochloride) and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. Metformin HCl has poor compressibility, and high water solubility (1 in 2). The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68.

Extended Release Formulations of Metformin HCl 1000 mg

Introduction :
Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide monohydrochloride) is not chemically or pharmacologically related to sulfonylureas, thiazolidinediones, or (alpha)-glucosidase inhibitors.

It is a white to off-white crystalline compound with a molecular formula of C4H12ClN5 (monohydrochloride) and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. Metformin HCl has poor compressibility, and high water solubility (1 in 2). The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68.

Extended Release Formulations of Metformin HCl 1000 mg by Wet Granulation

Introduction :
Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide monohydrochloride) is not chemically or pharmacologically related to sulfonylureas, thiazolidinediones, or (alpha)-glucosidase inhibitors.

It is a white to off-white crystalline compound with a molecular formula of C4H12ClN5 (monohydrochloride) and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. Metformin HCl has poor compressibility, and high water solubility (1 in 2). The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68.

How to Make Glucosamine And Chondroitin Capsule

Chondritin and Glucosamine are chondroprotective agents which have found application in the treatment and/or prevention of osteoarthritis and related disease of the joints, commonly used as dietary supplements. They are administered alone or in combination, normally in the form of a tablet or capsule.

Chondroitin effective in tissue repair and cartilage regeneration. Combinations of Glucosamine and Chondroitin are also effective in cartilage regeneration and joint maintenance. Chondroitin and Glucosamine act by increasing chondrocyte anabolic activity and sipressing degradative action of mediators on cartilage. This two materials are believed to be safer and less toxic than steroids or non-steroidal anti-inflammatory drugs commonly administered to treat arthritis and related musculo-skeletal disease.

Oral Pharmaceutical Compositions Containing Irbesartan

Irbesartan is a strong and long effective non-peptide tetrazole derivative and an angiotensin II type 1 receptor (AT1) antagonist. Its chemical composition is as follows: 2-butyl-3-[[2'-(lH-tetrazol-5-yl) [1, 1'-biphenyl]-4-yl] methyl] 1, 3-diazaspiro [4,4] non- 1-en-4-one. It is used alone or with other antihypertensive agents to treat high blood pressure. Irbesartan is clinically used alone as once-daily doses of 75 mg, 150 mg or 300 mg or combined with other antihypertensive agents to treat hypertension.

Irbesartan is a white crystalline powder that is slightly soluble in alcohol and methylene chloride and insoluble in water. The low aqueous solubility of irbesartan also presents a challenge, since, to keep the tablet mass small, only limited amounts of excipients may be added to facilitate wetting, disintegration, and ultimately, rapid and complete drug release The starting, without delay, of the antihypertensive property has a vital importance for the therapeutic activity of the formulation. For that purpose, the formulation's dissolution properties are determinant.

Formulation of Antacids Chewable Tablet

Most choose of the solid dosage form for antacid is chewable tablet. Generally, antacids has a big dose, and it is difficult to be directly swallowed and acid neutralizing antacid it would be better if chewed first. Chewable tablet was design to crush immediately in mouth using teeth (chewed), has a good residual taste, easy to swallow, and not leave a bitter taste or unpleasant taste.

Almost invariably, the formulation problem involves at least one of the following : undesirable taste, bad mouth-feel, or after taste. The desired product shloud prevent or minimize stimulation of the taste buds, contain a suitable flavor and sweetener, and achieve good mouth-feel and compressibility. Coating by wet granulation techniques are used to slove one or more of the above.

How to Make Glucosamine And Chondroitin Tablet/Caplet

Chondritin and Glucosamine are chondroprotective agents which have found application in the treatment and/or prevention of osteoarthritis and related disease of the joints, commonly used as dietary supplements. They are administered alone or in combination, normally in the form of a tablet or capsule.

Chondroitin effective in tissue repair and cartilage regeneration. Combinations of Glucosamine and Chondroitin are also effective in cartilage regeneration and joint maintenance. Chondroitin and Glucosamine act by increasing chondrocyte anabolic activity and sipressing degradative action of mediators on cartilage. This two materials are believed to be safer and less toxic than steroids or non-steroidal anti-inflammatory drugs commonly administered to treat arthritis and related musculo-skeletal disease.

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