Extended Release Formulations of Metformin HCl 500 mg

Introduction :
Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide monohydrochloride) is not chemically or pharmacologically related to sulfonylureas, thiazolidinediones, or (alpha)-glucosidase inhibitors.

It is a white to off-white crystalline compound with a molecular formula of C4H12ClN5 (monohydrochloride) and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. Metformin HCl has poor compressibility, and high water solubility (1 in 2). The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68.

Extended Release Formulations of Metformin HCl 1000 mg

Introduction :
Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide monohydrochloride) is not chemically or pharmacologically related to sulfonylureas, thiazolidinediones, or (alpha)-glucosidase inhibitors.

It is a white to off-white crystalline compound with a molecular formula of C4H12ClN5 (monohydrochloride) and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. Metformin HCl has poor compressibility, and high water solubility (1 in 2). The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68.

Extended Release Formulations of Metformin HCl 1000 mg by Wet Granulation

Introduction :
Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide monohydrochloride) is not chemically or pharmacologically related to sulfonylureas, thiazolidinediones, or (alpha)-glucosidase inhibitors.

It is a white to off-white crystalline compound with a molecular formula of C4H12ClN5 (monohydrochloride) and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. Metformin HCl has poor compressibility, and high water solubility (1 in 2). The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68.

How to Make Glucosamine And Chondroitin Capsule

Chondritin and Glucosamine are chondroprotective agents which have found application in the treatment and/or prevention of osteoarthritis and related disease of the joints, commonly used as dietary supplements. They are administered alone or in combination, normally in the form of a tablet or capsule.

Chondroitin effective in tissue repair and cartilage regeneration. Combinations of Glucosamine and Chondroitin are also effective in cartilage regeneration and joint maintenance. Chondroitin and Glucosamine act by increasing chondrocyte anabolic activity and sipressing degradative action of mediators on cartilage. This two materials are believed to be safer and less toxic than steroids or non-steroidal anti-inflammatory drugs commonly administered to treat arthritis and related musculo-skeletal disease.

Oral Pharmaceutical Compositions Containing Irbesartan

Irbesartan is a strong and long effective non-peptide tetrazole derivative and an angiotensin II type 1 receptor (AT1) antagonist. Its chemical composition is as follows: 2-butyl-3-[[2'-(lH-tetrazol-5-yl) [1, 1'-biphenyl]-4-yl] methyl] 1, 3-diazaspiro [4,4] non- 1-en-4-one. It is used alone or with other antihypertensive agents to treat high blood pressure. Irbesartan is clinically used alone as once-daily doses of 75 mg, 150 mg or 300 mg or combined with other antihypertensive agents to treat hypertension.

Irbesartan is a white crystalline powder that is slightly soluble in alcohol and methylene chloride and insoluble in water. The low aqueous solubility of irbesartan also presents a challenge, since, to keep the tablet mass small, only limited amounts of excipients may be added to facilitate wetting, disintegration, and ultimately, rapid and complete drug release The starting, without delay, of the antihypertensive property has a vital importance for the therapeutic activity of the formulation. For that purpose, the formulation's dissolution properties are determinant.

Formulation of Antacids Chewable Tablet

Most choose of the solid dosage form for antacid is chewable tablet. Generally, antacids has a big dose, and it is difficult to be directly swallowed and acid neutralizing antacid it would be better if chewed first. Chewable tablet was design to crush immediately in mouth using teeth (chewed), has a good residual taste, easy to swallow, and not leave a bitter taste or unpleasant taste.

Almost invariably, the formulation problem involves at least one of the following : undesirable taste, bad mouth-feel, or after taste. The desired product shloud prevent or minimize stimulation of the taste buds, contain a suitable flavor and sweetener, and achieve good mouth-feel and compressibility. Coating by wet granulation techniques are used to slove one or more of the above.

How to Make Glucosamine And Chondroitin Tablet/Caplet

Chondritin and Glucosamine are chondroprotective agents which have found application in the treatment and/or prevention of osteoarthritis and related disease of the joints, commonly used as dietary supplements. They are administered alone or in combination, normally in the form of a tablet or capsule.

Chondroitin effective in tissue repair and cartilage regeneration. Combinations of Glucosamine and Chondroitin are also effective in cartilage regeneration and joint maintenance. Chondroitin and Glucosamine act by increasing chondrocyte anabolic activity and sipressing degradative action of mediators on cartilage. This two materials are believed to be safer and less toxic than steroids or non-steroidal anti-inflammatory drugs commonly administered to treat arthritis and related musculo-skeletal disease.