Chondritin and Glucosamine are chondroprotective agents which have found application in the treatment and/or prevention of osteoarthritis and related disease of the joints, commonly used as dietary supplements. They are administered alone or in combination, normally in the form of a tablet or capsule.

Chondroitin effective in tissue repair and cartilage regeneration. Combinations of Glucosamine and Chondroitin are also effective in cartilage regeneration and joint maintenance. Chondroitin and Glucosamine act by increasing chondrocyte anabolic activity and sipressing degradative action of mediators on cartilage. This two materials are believed to be safer and less toxic than steroids or non-steroidal anti-inflammatory drugs commonly administered to treat arthritis and related musculo-skeletal disease.

The manufacture of solid dosage forms containing chondroitin and/or Glucosamine has been problematic. Glucosamine HCl has poor compressibility, and chondroitin sulfate derived from marine life has low bulk density and poor flowability. Therefore, the amount of chondroitin and glucosamine which can be contained in a single tablet has been limited. Tablets have to be extremely large or a large number of tablets must be taken in order to administer effective amounts of the compounds. The dominant mechanism of compression of glucosamine HCl powder was brittle fracture, whereas wet granulated glucosamine HCl exhibited plastic deformation with enhanced mechanical strength..

Chondroitin sulfate was extremely hygroscopic and deliquescent. If you touch and feel the chondroitin powder, it feels “melting” on your fingers, and sticky. That’s why, during process production, the relative Humidity should be maintenance. RH under 40% is necessary. If you don’t have controlled room automatically you can use Dehumidifier. Relative Hunidity is very influential. While I try to compress the Glucosamine and Chondroitin granule, is sticky on the tablet compression’s punch and dies (RH >50%).

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