Method to Increase Dissolution Tablet : Pre-formulation and Batch Production Rework

Many factors affected the dissolution tablet :
  • Type, Concentration and solubility of Active Ingredient
  • Type and Concentration of Binder Used
  • Type and Concentration of Fillers Used (soluble vs. insoluble)
  • Type and Concentration of Lubricant Used
  • Type of Dissolution testing Used (Apparatus, Speed, Media)
  • Manufacturing Process (wet granulation vs. compaction vs. direct compression)
  • Hardness of tablet
  • Disintegration time of tablet
  • and many others factors.
Before tablet starts to dissolve, tablet should disintegrate first. So, where tablet begins to disintegrate? Ordinary tablet (immediate release tablet) starts to disintegrate in gastrointestinal tract. GI tract provides sufficient fluid to facilitate disintegration of the dosage form and dissolution of the drug.

Type and Mechanism of Tablet Disintegrant

Disintegrant is an excipient which is added to a tablet or capsule blend to aid in the break up of the compacted mass when it is put into a fluid environment. This is especially important for immediate release products where rapid release of drug substance is required.Disintegrant can be used with products that are wet granulated, dry granulated and direct compression. In wet granulation formulations, the disintegrant is normally effective when incorporated into the granule (intragranularly). It may be more effective if added 50% intragranularly, and 50% extra-granularly.

The simplest way to achieve quick disintegration is to use a superdisintegrant in concert with suitable diluents. Superdisintegrants such as croscarmellose sodium, crospovidone, and sodium starch glycolate are frequently used in tablet formulations to improve the rate and extent of tablet disintegration and thereby increase the rate of drug dissolution.

Paracetamol/Acetaminophen Tablet Formulation Using Cheap and Simple Ingredients with Wet Granulation Method

How to make paracetamol/Acetaminophen tablet commercially?
Paracetamol or also known as Acetaminophen has been very well known as analgesic and antipyretic drug. Actually, this tablets were sold as OTC drug or even prescribed by doctors with high value of prize. Don’t you know, it’s easy to make and all ingredients were easy and cheap to purchased.

It is well known that paracetamol exhibits poor compressibility during compaction, often resulting in weak and unacceptable tablets with a high tendency to cracking and sticking.

The active ingredients, paracetamol, is easy to purchased, so does the other ingredients. The ingredients used to produced paracetamol tablets are:
  1. Paracetamol/Acetaminophen ( Active ingredients)
  2. Maize Starch (Binder)
  3. Croscarmellose (Desintegrant)
  4. Nipagin/Methyl Paraben (Preservative)
  5. Nipasol/Propyl Paraben (Preservative)
  6. Purified Water
  7. Talc (antisticking)
  8. Silicon Dioxide Colloidal (antiadherent)
  9. Magnesium Stearate (Lubricants)

Effervescent Tablet Formulation and Manufacture

What you should know about effervescent forms before formulate and manufacture it? As per revised definition proposed to US FDA, Effervescent tablet is a tablet intended to be dissolved or dispersed in water before administration. Effervescent tablets are uncoated tablets that generally contain acid substances and carbonates or bicarbonates and which react rapidly in the presence of water by releasing carbon dioxide. They are intended to be dissolved or dispersed in water before use. You will find the process of Effervescent Tablet Formulation and Manufacture here.

Many studies have demonstrated that effervescent tablets and powders enhance absorption of a number of active ingredients, such as disulfiram and caffeine. That’s because the carbon dioxide created by the effervescent reaction can induce enhanced active-ingredient permeability due to an alteration of the paracellular pathway. It is theorized that the carbon dioxide alters (widens) the intercellular space between cells, which leads to greater absorption of active ingredients (both hydrophobic and hydrophilic).

Read more about :Vitamin C Effervescent Tablet : Formula, Manufacturing and Consideration of Material and Method of Manufacture Selection