Many factors affected the dissolution tablet :
  • Type, Concentration and solubility of Active Ingredient
  • Type and Concentration of Binder Used
  • Type and Concentration of Fillers Used (soluble vs. insoluble)
  • Type and Concentration of Lubricant Used
  • Type of Dissolution testing Used (Apparatus, Speed, Media)
  • Manufacturing Process (wet granulation vs. compaction vs. direct compression)
  • Hardness of tablet
  • Disintegration time of tablet
  • and many others factors.
Before tablet starts to dissolve, tablet should disintegrate first. So, where tablet begins to disintegrate? Ordinary tablet (immediate release tablet) starts to disintegrate in gastrointestinal tract. GI tract provides sufficient fluid to facilitate disintegration of the dosage form and dissolution of the drug.

Accelerate Disintegration Time of Tablet
The higher the tablet hardness, time for tablet to disintegrate will be longer, dissolution may be delayed. So, what can you do to your formula to accelerate disintegration time?

1. You can reduce the tablet hardness. But, when you decide the hardness range, you also should watch the friability of the tablet. Sometimes, if you reduce the hardness of the tablet, the friability also will reduce. If tablet too brittle, you will find some trouble when you coat the tablet (if it’s a coated tablet). To get the appropriate tablet hardness, you may try some trial to get it.

2. Add Disintegrant. Disintegrant is an excipient which is added to a tablet or capsule blend to aid in the break up of the compacted mass when it is put into a fluid environment. This is especially important for immediate release products where rapid release of drug substance is required.

3. Add Surfactant.
The addition of a surfactant into a tablet formulation appears to be attractive method of improve the drug release rate. The improved release rate is often associated with the effect of surfactant increasing the hydrophilicity of the dosage form thereby promoting drug dissolution. The findings of this investigation showed tha the presence of surfactant infulenced the tablet disintegration rate, producing a finer dispersion of disintergrated particles. It follows that the action of surfactant improving drug dissolution from tablets may be attributed ot the aciton of surfactnat producing fine disintegrated particles with correspondingly larger surface area for drug dissolution. It was also demonstrated that upon tablet disintergration the disinstegrated particles have a tri-moal frequency distribution.