Rosuvastatin Tablet Formulation and Manufacturing

Manufacturing of stable tablet containing rosuvastatin can not be accomplished only by using pH adjuvant compounds. Presence of inorganic salts of multivalent metals is also required to prevent the formation of lactone and oxidation decomposition products. Stability of statin also can be obtained by adding amino sugars (e.g. N-methyl-glucoseamine). The advantage of the amino sugars versus inorganic alkali-earth metal salts is that they do not irritate the mucosa in the intestines, but of course tht prize is higher.

In the pharmaceutical composition inorganic salts of multivalent metals (Ca, Mg, Zn, Al, Fe and the combinations thereof) are used as stabilizing additives such as aluminum, magnesium metasilicate, tribasic calcium phosphate, tribasic magnesium phosphate and tribasic aluminum phosphate. The marketed (under Crestor trade name) pharmaceutical composition contains tribasic calcium phosphate as stabilizing agent.

It is known from the literature that from among HMG-CoA reductase inhibitor, lipid-lowering drugs several compounds are sensitive to the properties of the micro-environment of the composition, in fact to light, to heat and humidity.


Handrub for Hygienic and Surgical Hand Disinfection Formula

Formula, Ingredients and Chemical-physical Data 

Handrub such as Desmanol® is a rapid acting alcohol based handrub for hygienic and surgical hand disinfection. Its unique formulation allows for frequent use and emollient ingredients help prevent the skin from drying out

At a glance
  • Desmanol® has a broad spectrum of activity and is effective against MRSA and VRE, bacteria ( inlc. TB bacilli), fungi, viruses (polio, vaccina, adeno, herpes, herpes simplex viruses, HAV, HBV, HCV, HIV)
  • Suitable for both hygienic and surgical hand disinfection
  • Contains emollients for skin care protection
  • Suitable for frequent use without causing sticky residue 
 Composition :
  • Active Ingredient : 1-propanol, 2-propanol, and Chlorhexidine digluconate
100g solution contains : 45 g propan-1-ol and 28g propan-2-ol
  • Other Ingredient: Macrogol 400, 1-Tetradecanol, Nonoxynol-12, Macrogol-iso-octanoate-220

The Application of Starch 1500 (Pregelatinized Starch) in Solid Dosage Form

Pregelatinized starches have been used for a long time in the food industry, so does in Pharmaceutical industries. Starch 1500 is a unique pharmaceutical excipient combining several properties in a single product.
Starch 1500 had multiple functions, such as binder, disintegrant, and flow-aid while having lubricant properties. It is extremely versatile, being effective in a variety of processing methods for solid oral dosage forms, such as direct compression, wet granulation, dry granulation/roller compaction and encapsulation. Starch 1500 is particularly effective with moisture sensitive actives and low dose applications and exhibits synergy, enhancing the functionality of other commonly used excipients in formulations.

The Advantages of Pregelatinized Starch (Starch 1500)
Starch 1500 also has self-lubricating properties, which reduces the need for high levels of lubricants, thus improving mechanical strength and dissolution of the product.

Pregelatinized starches had ability to thicken or gel promptly without the application of a substantial amount of heat necessary with normal starches. However, this ability to rapidly thicken or gel creates problems when these materials are used in dry products to be reconstituted in small portions by the ultimate consumer.

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