TABLET - SOLID DOSAGE FORM

  • Tablets are solid dosage form containing ingredients with or without filler material.
  • Based on the method of manufacture, can be classified as a printed tablet and compressed tablet
  • Compressed tablets are made with high pressure in powder or granule using a steel mold
  • Printed tablet made by pressing the moist powder mass with low pressure into the mold hole. The density of the tablet depends on the bond crystals formed during the drying process, it has been very rarely used 
FORMS & CLASSIFICATION of TABLET
Based on the route of administration or its functions, drug delivery systems and forms and methods of manufacture, the tablet can be classified as follows:

1. Oral tablets for Eaten

• Compressed Tablets / CT
• Double Layer/Multiple Compressed Tablets / MCT)
  -Coated Tablets
  -Felt a coated tablet
• Tablet with repeated reaction
• Sugar coated and Sugar chocolate coated tablet
• Film-coated tablet
• Chewing Tablet

2. Tablets Used in Mouth cavity

• buccal tablet
• Sublingual Tablets
• Troche or lozenges

3. Tablet Provided by Other Routes

• Implantation Tablet
• Vaginal Tablets

4. Tablets Used To Make Solvent

• effervescent tablets
• hypodermic tablet
• Triturat tablets

LUBRICANTS USED in WET GRANULATION

Optimum concentration: 1%
Function: as an excipient to eliminate friction during tablet compression and drawing out the mold

Type:
a. Water soluble: widely used for water-soluble tablet such as tablet / powder effervescent
b. Water insoluble: the most widely used and used in low concentrations

Mechanism:
a. Fluid type lubricant
Form a liquid layer between the compressed mass with metal molds. Can leave stains on the tablet
b. Boundary type lubricant
With the interaction between polar groups with the lubricant molecules on metal surfaces. This type has better adheren to the mold

Preparation of Theophylline Tablets with Direct Compression Method

Direct Compression is the ingredients of a mixture of pulverulent materials without initial process. The advantage of this method is that the ingredients are moist and heat sensitive, that stability operations disrupted by granulation can be made into tablets. But only a few drugs that can be made by direct compression, without further processing and without excipient. If at the time of compression produces a small tablet form, it is caused by the formation of cohesive force between powder particles during compression.

Excipient should be to improve the flow properties and through holding capacity enhancements allow printing of compact powder and cause mold.

In this experiment, the compressing method used is Theophylline because Theophylline has a good flow properties. Supplies are used as filler is Avicel. Avicel is used as filler because of the good flowability so as to reduce the deviation of mass, a high swelling power causes a short tablet disintegration time. Avicel insoluble in water, can be made very pure, chemically neutral and is a poor medium for microorganisms.

Other excipient is starch, which is used as disintegrant with a look at the literature, it turns starch has long been known that some compounds can be compressed after addition of 10-12% starch. Addition of starch to function as a regulator of the flow as well as binders.

Talc is used as glidant, because the task of the talc is to improve the flow of material to be compressed. Reducing the mass deviation and increase the accuracy of the size of the tablet. Mg stearate is used as a lubricant to reduce friction of metal and friction making it easier for expenditure the tablets from the mold.

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