Many materials commonly used in lipsticks are easily oxidized in air and produce an unpleasant odor, or smell rancid. Therefore, antioxidants are advised to be added to the formulation of lipstick or for some material that is stored for a long time with the appropriate antioxidant.

Antioxidants are commonly used in lipsticks are: BHA, BHT, propyl gallate, citric acid, oil-soluble compounds such as vitamins A, E, B, and C that act as antioxidants and free radical absorbent. These compounds are used respectively about 0.5% depending on the nature of the products listed on the label.

The most frequently used antioxidants are the Beta-carotenes (provitamins A), ascorbic acid, and tocopherols, the which are all powerful, natural antioxidants.