Hard gelatin capsules have some type of size and various colors. The use of course depends on the dose of the active ingredient itself. The greater the dose the greater the size of the capsule is used. Addition of excipient is also a basic selection of capsule size.
Ideally, in designing or formulating drug in capsule dosage form, the less excipient which added even more good. However, rarely a capsule consisting of only one type of material is its active ingredient.
Many factors must be considered in adding ingredient materials. The first step in making capsule of course of study preformulation. We must know beforehand how the chemical and physical properties of active ingredients, and then we can make the estimation formula.
Here is a table : size of the capsule, the capsule volume and weight of the contents of the capsule based on the density of powder
| Capsule Size | Capsule Volume in ml | Capasity in mg powder density | |||
|---|---|---|---|---|---|
| 0.6 g/ml | 0.8 g/ml | 1.0 g/ml | 1.2 g/ml | ||
| 000 | 1.37 | 822 | 1096 | 1370 | 1644 |
| 00 el | 1.02 | 612 | 816 | 1020 | 1224 |
| 00 | 0.91 | 546 | 728 | 910 | 1092 |
| 0 el | 0.78 | 468 | 624 | 780 | 936 |
| 0 | 0.68 | 408 | 544 | 680 | 816 |
| 1 | 0.50 | 300 | 400 | 500 | 600 |
| 2 | 0.37 | 222 | 296 | 370 | 444 |
| 3 | 0.30 | 180 | 240 | 300 | 360 |
| 4 | 0.21 | 126 | 168 | 210 | 252 |
| 5 | 0.10 | 78 | 104 | 130 | 156 |
