- These are hydrophilic substances and soluble in water
- PEGs are used alone as hydrophilic plasticizers in film coating
- Rate of release of water soluble drugs decreases with increase in the molecular weight of PEGs.
- The PEG with molecular weight of 6000 and above decreases plasticizing effect and increases lubricants effect
- Migration of PEG can occur from the tablet film coating leading to interactions with core compounds.
- These are esters of n-butanol and saturated dibasic acids.
- Principally used as plasticizers in film coating.
- For film coating as a plasticizer, DBS is used in 10-30% concentration by weight of polymer.
- Solubility : Insoluble in water but soluble in ethanol, mineral oil, etc
- Quite suitable for solvent based coating dispersion.
DEP (Di-Ethyl Phthalate)
- Used both as a solvent and plasticizer
- Non toxic, non irritant
- DEP is used as a plasticizer in film coating of tablets, beads and granulates at a concentration of 10-30% W/W of polymers
- Solubility : insoluble in water, soluble in ethanol, ether and organic solvents
- It is volatile in nature
- Also known as kodaflex DBP
- Solubility : Very soluble in acetone, benzene, ethanol, ether and soluble in water
- Is principally used as a plasticizer
- But it has limited compatibility with the cellulose acetate polymers
- Also known as Triethyl glycerin or glycerol triacetate
- Used as both plasticizer and a solvent
- Its as hydrophilic plasticizers
- This plasticizer is suitable for both aqueous and solcent based polymeric coating of tablets, granules and beads in concentration of 10-35% by weight of polymer.
- Miscible with water as well as in ether, ethanol, choloroform , etc
- It is a citric acid ethyl esters
- Also known as Citroflex 2
- Its is principally used as plasticizer
- It is effectively used in aqueous based coating in oral sustained or enteric coated tablets
- Miscible with water
