Blister packs can help patients follow drug regimens, protect drugs over a long shelf life, and are portable. Five aspects which blister packaging is better than conventional packaging.
  • product integrity
  • product protection
  • tamper evidence
  • reduced possibility of accidental misuse
  • patient compliance
  • Blister packs are very inexpensive to produce.
  • Can be custom fit to help sell/promote products.
  • Protects and holds the product securely.
  • Many sizes available, from small unit-dose pills to large suit-case sized blisters.
  • Allows products to be seen, but not touched, product is very visible.

The Advantages of Blister Packs

Product integrity. Blister packaging helps retain product integrity because drugs that are prepackaged in blisters are shielded from adverse conditions. Furthermore, opportunities for product contamination are minimal, and each dose is identified by product name, lot number, and expiration date. Therefore, blister packaging ensures product integrity from the producer directly through distribution to the consumer.

Product protection. Blister packaging protects pharmaceuticals in the home better than bottles do. Blister packaging, keeps each tablet or capsule hermetically sealed in its own bubble. Drugs that are not taken remain in the original package and are fully protected against external conditions. A blister protects a moisture-sensitive tablet right up to administration. In contrast, the moisture in the headspace of a multiple-unit bottle is replaced each time the bottle is opened.

Tamper evidence. The dosage units are individually sealed in constructions of plastic, foil, and/or paper. The package must be designed so that one must tear the compartment to get at the product, and it must not be possible to separate the backing materials from the blister without leaving evidence. Once a bottle has been opened, whatever tamper-evident mechanism it had is gone. With blister packaging, however, each tablet or capsule is individually protected from tampering until use, so any form of tampering with a blister package is immediately visible.

Possibility of accidental misuse. Blister packaging can be made child resistant. Most child-resistant blister packages contain a paper/film layer with a peelable adhesive. Patients must peel the adhesive away from the foil backing before the pill can be pushed through. Specifying 15-mil polyvinyl chloride (PVC) blister stock provides extra security because it is less likely that children could puncture the package by biting through it. Companies also are experimenting with bitter coatings to deter children from putting packages in their mouths.

Patient compliance. As many as 30% of all prescriptions are not taken properly initially, and as many as 50% are not continued after one year. Such misuse can cause a range of adverse drug reactions, including death.

Blister packs can be bar coded for use in hospitals and nursing homes to prevent errors in distributing medication. Pharmacists have a greater opportunity to communicate with and advise their patients because less time is necessary to fill the prescription.