Film for blister packaging is requiring compliance with shelf-life standards and protection from gas, moisture, chemicals, and extraneous microbiological and particulate contamination. The ability to precisely control film specifications for blister packaging enables this technique to be used to make specialized products such as child-resistant packaging. The technology for creating child-resistant packaging involves using seals, custom plastic banding, and container closures that must be pressed, twisted, or mechanically manipulated for entry. Foil webs require push-through or puncture to gain entry, and complete plastic tubes are used to totally enclose a package. Medical applications of blister packaging include surgical instruments, medical pouches, implantable devices, diagnostic test kits, and disposables.


One important application of blister film involves using various combinations of polyvinyl chloride, polyvinylidene chloride, polyethylene terephthalate, and foils to create a lidding structure with a cover sheet through which a pharmaceutical tablet or capsule can be pushed.


Type of Polymer Used for Blister

Materials of Construction / Type Critical Properties Area of use
PVC 200/250/350
Low barrier / Simple unit
pack / Aesthetic
Stable products like Paracetamol,  Co-trimoxazole, certain softgel capsules
PVC / PVdC (250/40) Low barrier better than PVC Products not very sensitive to moisture, gases and with moderate self life- Multivitamin tablets and capsules
PVC / PVdC (250/60)/ (250/90)/ (250/120) Good barrier Moderate to high sensitive range of products, certain FDC/ Enzyme products
PVC / PE / PVdC (200/25/60)/ (250/25/90)(300/30/90) Good barrier
Quite high sensitive range of products-4 FDC (RHZE)
Ultrasafe Duplex High barrier/economical Quite high sensitive range of products
Ultrasafe Triplex High barrier/economical Quite high sensitive range of products

PVC/Aclar (10μ to 100μ) 
PVC/COC, PE/COC

Excellent barrier Extremely moisture sensitive range of products

OPA/Al foil/PVC
Alu/Alu

Excellent barrier
Extremely sensitive range of products – 
Cefuroxime Axetil tablets, Levocetirizine Tablets

OPA/Al foil/PVC
 Alu/Alu with desiccant

Excellent barrier Extremely moisture sensitive range of products

Aluminium foil with HSL
(Hard tempered) 0.02 / 0.025
 
Excellent barrier Lidding foil for blister packing

Aluminium foil
(Hard tempered with special coating)
Excellent barrier Lidding foil for COC
Aluminium foil / poly (30 –40 microns (soft tempered) Excellent barrier For strip packing use of very sensitive range of products – Omeprazole Capsules, Ranitidine Tablets etc.,
Aluminium foil / VMCH (30 –40 microns (soft tempered) Excellent barrier
For strip packing use of dark colored  sugar
coated tablets
Paper /Poly
Very low barrier / Simple unit
pack / Aesthetic look
Very economical pack for very stable products
Paper/Al/HSL Excellent barrier For Child resistance blisters pack

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