Each 5 ml of Paracetamol Elixir contains :

Ingredients Weight Function
Paracetamol 120 mg Active ingredient
Glycerolum 2.5 ml Solubelizer
Propyleneglycol 0.5 ml Diluent
Sorbitol solution 70% 1.25 ml Sweetening agent
Ethanol 0.5 ml Diluent
Flavoring agent qs
Coloring agent qs
Preservative agent qs
Purified agent qs
  • Paracetamol solubility: Soluble in 70 parts of water, and in 7 parts ethanol (95%) P, in 13 parts of acetone P, in 40 parts of glycerol P, and in 19 parts propylenglycol P, soluble in alkali hydroxide solution.
  • Sorbitol: is hygroscopic, easily soluble in water and sparingly soluble in ethanol.
  • Propylenglycol: can be mixed with water and ethanol 95%.
  • Glycerol: can be mixed with water and ethanol.
Solubility data is very useful in preparations, which include sequences or a mix of each ingredient must be strictly in accordance with the nature and solubility. If seen from the solubility then we know that the function of glycerol and propylenglycol is to enhance the solubility of the medicine that is useful to maintain the stability of the drug.

Dose Calculation

Standard dose:
Children up to 1 year = 1 tsp (5 ml)
1-5 years = 2 tsp (10 ml)

Calculation and Weighing Ingredients of Paracetamol Elixir 60 ml

Ingredients Calculation Weight
Paracetamol 120 mg x 12 1440 mg
Glycerolum 2.5 ml x 12 30 ml
Propyleneglycol 0.5 ml x 12 6 ml
Sorbitol solution 70% 1.25 ml x 12 15 ml
Ethanol 0.5 ml x 12 6 ml
Apple essence qs
Green Coloring agent qs
Benzoic acid qs 2 ml
Purified water ad 60 ml

Procedure and Manufacturing of Paracetamol Elixir
  1. Weight Paracetamol, reduce the particle size by sieve it with mesh 20, then place it in erlenmeyer → dissolve it in measured ethanol.
  2. Measure propylenglycol, place it in erlenmeyer → stir
  3. Measure glycerol, place it in erlenmeyer → stir
  4. Measure Solutio Sorbitol 70%, place it in erlenmeyer → stir ad homogeneous. Sol Sorbitol was entered the last one because it slightly soluble in ethanol. If it entered first, the solution will not mixed well and the other solution will be difficult to mix.
  5. Calibration bottle. The homogenous solution entered in the bottle, then add aqua ad 80 ml.
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